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ea0092op-13-02 | Oral Session 13: Pathophysiological actions of thyroid hormones | ETA2023

Induced types 2 and 3 deiodinase in the muscle of critically ill patients correlates with endoplasmic reticulum and mitochondria alterations: Implications to nonthyroidal illness syndrome pathophysiology

Wajner Simone , Braun Andre , Marschner Rafael , Oliveira Thaliane , Argenti Gustavo , Vidart Josi

Dysregulation of types 2 and 3 deiodinases (D2 and D3) alters the metabolism of thyroid hormones in the patients with nonthyroidal illness syndrome (NTIS). Previous studies have demonstrated that deiodinase expression varies in the muscle in different disease models. Nevertheless, the location of D2 and D3 and the effect of oxidative stress on reticulum endoplasmic (ER) and mitochondrial function are not described in human muscle with different types of acute disease and NTIS....

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ea0092ps2-19-01 | Thyroid Hormone Transport & Metabolism Basic | ETA2023

Types 2 and 3 deiodinase are induced in blood cells of critical ill patients: Implications to nonthyroidal illness syndrome pathophysiology

Oliveira Thaliane , Dheher Milla , Braun Andre , Vidart Josi , Marschner Rafael , Kotzian Bruno , Ulian Bruna , Wajner Simone

Dysregulation of types 2 and 3 deiodinases (D2 and D3) are present and profoundly alters the metabolism of thyroid hormones in the nonthyroidal iIllness syndrome (NTIS). The activation of this enzyme in peripheral blood cells can be one of the factors that alters the progression of this syndrome. However, the effect of oxidative stress on D3 expression in these cells from ill patients is unknown.ObjectiveEvaluate the presence and variations of D3 expression in the granulocytes...

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Endocrine Abstracts

Induced types 2 and 3 deiodinase in the muscle of critically ill patients correlates with endoplasmic reticulum and mitochondria alterations: Implications to nonthyroidal illness syndrome pathophysiology

Types 2 and 3 deiodinase are induced in blood cells of critical ill patients: Implications to nonthyroidal illness syndrome pathophysiology

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